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Search Results for " positive allosteric modulator "

20

Compounds

Cat No. Product Name Synonyms Targets
T4573 Cyclothiazide GluR
Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptorsthat potently inhibits AMPA receptor desensitization, positively modulating its response to glutamic acid (EC50 = 3.8 M).
T26869 BMS-986122 BMS 986122 Opioid Receptor
BMS-986122 (BMS 986122) is a positive allosteric modulator of μ-opioid receptors that increases β-arrestin recruitment stimulated by endomorphin 1 in U2OS-OPRM1 human osteosarcoma cells expressing μ-opioid receptors (EC5...
T28069 ML380 ML 380,ML-380 AChR
ML380 is a highly potent and the first CNS penetrant M5 positive allosteric modulator (PAM).
T29137 VU0453595 VU 0453595,VU-0453595 AChR
VU0453595 is a M1 positive allosteric modulator (PAM).
T8776 FEMA 4774 S9632 Others
FEMA 4774 (S9632) is a positive allosteric modulator of T1R2/T1R3. FEMA4774 shows obvious enhancement of the sweetness of sucrose in sensory evaluation tests
T23469 TQS 4-Naphthalen-1-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide AChR
TQS (4-Naphthalen-1-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide) is a positive allosteric modulator of α7 nACh receptors.
T1884 CX516 Ampakine CX516,BDP 12,Ampalex GluR , iGluR
CX516 (Ampalex), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI).
T60047 V-0219 Glucagon Receptor
V-0219 is a positive allosteric modulator of GLP-1 and can be used in studies about obesity-associated diabetes.
T4522 SSD114 HCl GABA Receptor
SSD114 is a novel GABAB receptor positive allosteric modulator.
T23481 U 89843A GABA Receptor
Positive allosteric modulator of GABAA receptors
T10573 BMT-145027 GluR
BMT-145027 is a positive allosteric modulator of mGluR5 without inherent agonist activity (EC50 = 47 nM).
T29126 VU0360172 VU-0360172,VU 0360172 GluR
VU0360172 is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM).
T15942 MK-7622 M1 receptor modulator AChR
MK-7622 (M1 receptor modulator) is a modulator of muscarinic M1 receptor positive allosteric.
T16126 Monepantel AAD1566 Others
Monepantel is an organic anthelmintic. Monepantel is also used for a positive allosteric modulator of a nematode-specific clade of nicotinic acetylcholine receptor (nAChR) subunits.
T27405 GAT211 GAT-211,AZ-4,GAT 211,AZ 4,AZ4
GAT211 is a CB1 positive allosteric modulator. GAT211 suppresses allodynia and produces synergistic antiallodynic effects with monoacylglycerol lipase and fatty acid amide hydrolase inhibitors in paclitaxel-treated mice.
T27679 JNJ-39393406 AChR
JNJ-39393406 is an α7 nicotinic acetylcholine receptor positive allosteric modulator for the study of tobacco dependence and Alzheimer's disease.
T16402 Org-26576 GluR , iGluR
Org-26576 is a positive allosteric modulator of the AMPA receptor.
T6160 VU 0364439 GluR
VU 0364439 is a mGlu4 positive allosteric modulator (C50: 19.8 nM).
T29112 VPC171 VPC 171,VPC-171 Adenosine Receptor
VPC171 is a novel adenosine A1 receptor positive allosteric modulator (PAM).
T10432L AZD-8529 mesylate GluR
AZD-8529 mesylate is a highly selective, and orally bioavailable positive allosteric modulator of mGluR2 (EC50: 285 nM). It shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 ...
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